Substrate Incubation
Patient serum is applied to the Colorzyme® slide, where autoantibodies bind to antigens on Immuno Concepts’ proprietary substrates.
Pioneering A Simpler Path To Diagnosis With Colorzyme® Assays
Immuno Concepts' Colorzyme® test kits bring the reliability of our substrate production to a colorimetric format that any laboratory can read on a standard light microscope, no fluorescence equipment required.
Our Process
The Step-By-Step Science Behind Every Colorzyme® Diagnosis
Straightforward by design. Reliable by decades of research. This is how Colorzyme® test systems work.
Enzymatic Color Detection
An enzyme-conjugated secondary antibody is followed with color reagent powder (CRP), triggering a stable, permanent chromogenic reaction wherever autoantibodies are present.
Brightfield Pattern Interpretation
Your team reads the Colorzyme® diagnostic assay result under a standard brightfield microscope, where each permanent color deposit indicates a diagnosis.
This is what sets Colorzyme® assays apart: a process built on permanence, reproducibility, and simplicity.
Schedule a CallOur Solutions
The Full Spectrum Of Colorzyme® Test Kits
Every Colorzyme® assay in our portfolio is produced using the same proprietary technology, engineered in-house, validated lot by lot, and built to perform consistently across every run.
HEp-2000® uses a patented HEp-2 cell line genetically engineered to increase sensitivity to SS-A/Ro autoantibodies without affecting any other ANA pattern, is available in a Colorzyme® slide format. A critical advantage in conditions where SS-A/Ro positivity is frequently overlooked.
The original HEp-2 substrate blend that built Immuno Concepts’ identity is available as a Colorzyme® slide. Trusted for decades and produced to the same exacting standards, delivering reliable ANA pattern detection without fluorescence equipment.
The most widely recognized substrate for anti-DNA autoantibody detection in Colorzyme® diagnostic assay format. An established reference method for confirming anti-DNA positivity in patients with suspected systemic lupus erythematosus (SLE), accessible without a fluorescence microscope.
Why Choose Us
Why Laboratories Choose Colorzyme® Test Kits
Colorzyme® assays were developed for laboratories that want the diagnostic depth of indirect immunoassay testing without the overhead of fluorescence microscopy. Here's what makes every Colorzyme® test system different:
No Fluorescence Microscope Required
Our substrates are produced in-house using proprietary cell culture and tissue processes, ensuring superior morphology and fluorescence clarity across every run.
01Patented Color Reagent System
Our patented color reagent binds permanently at sites of autoantibody activity. This produces a stable chromogenic deposit that remains consistent, regardless of light source and optical filter configuration.
02Permanent, Archivable Results
Chromogenic deposits on Colorzyme® slides do not degrade over time. Results can be archived, reviewed, and shared for teleconsultation without any loss of pattern integrity, unlike fluorescent preparations, which photobleach on exposure to light.
03The Complete Range of Immunofluorescence Kits for Every Autoimmune Application
Colorzyme® test kits are not an afterthought. They are a direct extension of the manufacturing discipline, expertise, and quality standards that have made Immuno Concepts a trusted name in diagnostic immunoassay production.
Rigorous Lot Validation
Each lot of Colorzyme® assays is validated against reference sera before shipment. If a lot does not meet our quality thresholds, it does not leave our facility.
Proprietary In-House Substrate Production
Our substrate preparation processes are developed and controlled in-house, giving us direct oversight of the substrate quality that defines your result.
Customized Laboratory Support
Every laboratory is different. We work with you to configure Colorzyme® test systems that fit your testing volume, clinical priorities, and existing workflow.
Education & Training Resources
We provide training, online tutorials, and ongoing education to help your team get the most from every Colorzyme® diagnostic assay in your workflow.
Global Distribution Network
Our international distribution network ensures laboratories everywhere have access to our full range of Colorzyme® test kits and the technical support to back them up.
Discover What Colorzyme® Test Kits Can Do For Your Laboratory
Whether you're expanding your autoimmune testing capabilities, reducing equipment overhead, or looking for a more accessible alternative to fluorescence-based methods, Colorzyme® test kits deliver the diagnostic precision your laboratory demands.